Isolation, pharmacology and gene organization of KPSFVRFamide: a neuropeptide from Caenorhabditis elegans.

@article{Marks1999IsolationPA,
  title={Isolation, pharmacology and gene organization of KPSFVRFamide: a neuropeptide from Caenorhabditis elegans.},
  author={Nikki J. Marks and Aaron G. Maule and Chengjun Li and Laura S Nelson and D. P. Thompson and Susan J Alexander-Bowman and Timothy G Geary and David W. Halton and Peter D E M Verhaert and Christopher Shaw},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={254 1},
  pages={
          222-30
        }
}
  • N. Marks, A. Maule, +7 authors C. Shaw
  • Published 8 January 1999
  • Biology, Medicine
  • Biochemical and biophysical research communications
To date, 53 peptides with C-terminal RFamides have been identified by the genome sequencing project in the nematode, Caenorhabditis elegans. In this study the FMRFamide-related peptide (FaRP) KPSFVRFamide (879.90 Da [MH]+) was structurally characterized from extracts of the nematode, Caenorhabditis elegans. Two copies of KPSFVRFamide are encoded by a gene designated flp-9. RT-PCR identified a single cDNA product which was confirmed as flp-9 by sequence determination. Flp-9 cDNA was isolated… Expand
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