Isolation, expansion and functional assessment of CD4+CD25+FoxP3+ regulatory T cells and Tr1 cells from uremic patients awaiting kidney transplantation.

@article{Berglund2012IsolationEA,
  title={Isolation, expansion and functional assessment of CD4+CD25+FoxP3+ regulatory T cells and Tr1 cells from uremic patients awaiting kidney transplantation.},
  author={David N. Berglund and Olle Korsgren and Tomas Lorant and Karin Schneider and Gunnar Tufveson and Bj{\"o}rn Carlsson},
  journal={Transplant immunology},
  year={2012},
  volume={26 1},
  pages={
          27-33
        }
}
BACKGROUND The immunosuppressive properties of regulatory T cells have emerged as an attractive tool for the development of immunotherapies in various disease contexts, e.g. to treat transplantation induced immune reactions. This paper focuses on the process of obtaining and functionally characterizing CD4+CD25+FoxP3+ regulatory T cells and Tr1 cells from uremic patients awaiting kidney transplantation. METHODS From October 2010 to March 2011 uremic patients awaiting living donor kidney… CONTINUE READING

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