Isolation, characterization and comparison of mammalian epidermal prekeratins.

  title={Isolation, characterization and comparison of mammalian epidermal prekeratins.},
  author={P. T. Bladon and Mark Taylor and Edward John Wood and William James Cunliffe},
  journal={Comparative biochemistry and physiology. B, Comparative biochemistry},
  volume={74 3},
1. The lower living layers of mammalian epidermis contain a cytoplasmic tonofilament protein, prekeratin, believed to be the precursor of the keratin which is found in the outer dead cell layer or stratum corneum. 2. Prekeratin is distinguished by its property of being extractable from epidermis homogenized in the presence of citric acid trisodium citrate buffer pH 2.65. 3. In the present study we have compared the epidermal prekeratins from ten mammalian species and have shown them to be of… CONTINUE READING