Isolation, characterization, cloning and expression of an alpha-neurotoxin from the venom of the Mexican coral snake Micrurus laticollaris (Squamata: Elapidae).

@article{CarbajalSaucedo2013IsolationCC,
  title={Isolation, characterization, cloning and expression of an alpha-neurotoxin from the venom of the Mexican coral snake Micrurus laticollaris (Squamata: Elapidae).},
  author={Alejandro Carbajal-Saucedo and Estuardo L{\'o}pez-Vera and Melisa B{\'e}nard-Valle and E. Noble Smith and Fernando Buend́ıa Zamudio and Adolfo Rafael de Roodt and Alejandro Olvera-Rodr{\'i}guez},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2013},
  volume={66},
  pages={64-74}
}
A new member of short chain α-neurotoxic protein family from venom of the Mexican coral snake, Micrurus laticollaris, was characterized. This protein, named MlatA1, possesses 61 amino acids with 8 conserved cysteine residues, sharing 30-91% sequence identity with other fully sequenced Micrurus toxins. MlatA1 (LD50i.v. = 0.064 mg/kg) antagonizes with both fetal and adult nicotinic acetylcholine receptor (nAChR) as well as α-7 neuronal nAChR in a dose-dependent way. Specific rabbit anti-Mlat… CONTINUE READING

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Heterologous expression, protein folding and antibody recognition of a neurotoxin from the Mexican coral snake Micrurus laticorallis

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