Isolation, characterization, and in rats plasma pharmacokinetic study of a new triterpenoid saponin from Dianthus superbus

  title={Isolation, characterization, and in rats plasma pharmacokinetic study of a new triterpenoid saponin from Dianthus superbus},
  author={Yina Ren and Xiaobao Xu and Qianlan Zhang and Yongzhuang Lu and Ximin Li and Lin Zhang and Jingkui Tian},
  journal={Archives of Pharmacal Research},
One new oleanolic acid triterpenoid saponin, 3-O-β-d-glucopyranosyl olean-11, 13(18)-diene-23,28-dioic acid, (hereafter referred to as DS-1) was isolated from the traditional Chinese medicinal plant Dianthus superbus (D.superbus). DS-1 plays an important role in the bioactivity of D. superbus. Thus, a sensitive, reliable and accurate reversed-phased liquid chromatography with tandem mass spectrometry (LC–MS/MS) in negative ion mode was developed and validated for the quantification and… Expand
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