Isolation, characterization, and distribution of an unusual pancreatic human secretory protein.

@article{Gross1985IsolationCA,
  title={Isolation, characterization, and distribution of an unusual pancreatic human secretory protein.},
  author={Johannes Gross and Rolf I. Carlson and Andrew W. Brauer and Michael N. Margolies and Andrew L Warshaw and Jack R Wands},
  journal={The Journal of clinical investigation},
  year={1985},
  volume={76 6},
  pages={
          2115-26
        }
}
An unusual protein was isolated from acid extracts of normal human pancreas and pancreatic secretion in the form of uniform 7-10-nm long single threads without visible axial periodicity or other structure, as seen in the electron microscope. It accounts for as much as 300 micrograms/ml in some pancreatic secretions as measured by specific radioimmunoassay. The protein undergoes a freely reversible, pH dependent, globule-fibril transformation, being stable in the fibril form between pH 5.4 and 9… CONTINUE READING

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