Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene.

@article{Inoue1996IsolationCA,
  title={Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene.},
  author={Hiroshi Inoue and Alan C. Riggs and Yukio Tanizawa and Kazuya Ueda and Akira Kuwano and Lingyi Liu and Helen Donis-Keller and M. Alan Permutt},
  journal={Diabetes},
  year={1996},
  volume={45 6},
  pages={789-94}
}
Insulin promoter factor 1 (IPF-1) is a homeodomain-containing protein that is thought to be a key regulator of pancreatic islet development and insulin gene transcription in beta-cells. This report describes the isolation and characterization of the human IPF-1 gene. The coding region, which showed 83% nucleotide identity with the mouse IPF-1 gene, was encoded by two exons that extended over a 5-kb region of human genome. The deduced human IPF-1 protein contained 283 amino acids, 1 amino acid… CONTINUE READING