Isolation, analytical measurements, and cell line studies of the iron-bryostatin-1 complex.

@article{Plummer2016IsolationAM,
  title={Isolation, analytical measurements, and cell line studies of the iron-bryostatin-1 complex.},
  author={Sydney Plummer and Thomas J Manning and Tess Baker and Tysheon McGreggor and Mehulkumar Patel and Greg Wylie and Dennis Phillips},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2016},
  volume={26 10},
  pages={
          2489-2497
        }
}
Bryostatin-1 is a marine natural product that has demonstrated medicinal activity in pre-clinical and clinical trials for the treatment of cancer, Alzheimer's disease, effects of stroke, and HIV. In this study, iron-bryostatin-1 was obtained using a pharmaceutical aquaculture technique developed by our lab that cultivates marine bacteria for marine natural product extraction. Analytical measurements (1)H and (13)C NMR, mass spectrometry, and flame atomic absorption were utilized to confirm the… Expand
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