Isolation, analytical measurements, and cell line studies of the iron-bryostatin-1 complex.

  title={Isolation, analytical measurements, and cell line studies of the iron-bryostatin-1 complex.},
  author={Sydney Plummer and Thomas J Manning and Tess Baker and Tysheon McGreggor and Mehulkumar Patel and Greg Wylie and Dennis Phillips},
  journal={Bioorganic \& medicinal chemistry letters},
  volume={26 10},
Bryostatin-1 is a marine natural product that has demonstrated medicinal activity in pre-clinical and clinical trials for the treatment of cancer, Alzheimer's disease, effects of stroke, and HIV. In this study, iron-bryostatin-1 was obtained using a pharmaceutical aquaculture technique developed by our lab that cultivates marine bacteria for marine natural product extraction. Analytical measurements (1)H and (13)C NMR, mass spectrometry, and flame atomic absorption were utilized to confirm the… Expand
6 Citations
Cell line studies and analytical measurements of three paclitaxel complex variations.
The copper(II) cation, sucrose, and hydroxychloroquine were complexed with the chemotherapy agent paclitaxel and studied for medicinal activity and molecular modeling was utilized to better understand the impact that species could have on physical parameters associated with Lipinski's Rule of Five. Expand
Pharmacokinetic studies of a three-component complex that repurposes the front line antibiotic isoniazid against Mycobacterium tuberculosis.
The percent growth values averaged over all 60 cell lines indicates the isoniazid-sucrose-copper-PEG-3350 complex has no anti-cancer activity, which suggests a lack of general toxicity and provides data for the complexes specificity against Mycobacterium tuberculosis. Expand
Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications.
This comprehensive account summarizes the recent progress in the development of bryostatins, including their total synthesis and biomedical applications, and provides an outlook on their future development. Expand
Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals
The use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy, and the application of a marine natural product extract as opposed to a single molecule as an antiviral agent are examined. Expand
Toll like receptors as a novel therapeutic target for natural products against chronic diseases.
This review is intended to summarize the recent progress on TLR association with CDDs and to list possible use of natural products, their combinations and their synthetic derivative in the prevention of TLR-driven CDD development. Expand
Targeting Toll like Receptors in Cancer: Role of TLR Natural and Synthetic Modulators.
Toll like receptors play vital roles in the process of carcinogenesis, hence TLR targeting is a promising approach for cancer prevention and the possible use of them as a therapeutic target is provided. Expand


Impact of environmental conditions on the marine natural product bryostatin 1
The results demonstrate that natural conditions transform bryostatin to a number of structures, including one with a molar mass of 806 Da, which has been previously identified in the sediment collected from the Gulf of Mexico. Expand
Copper ion as a delivery platform for taxanes and taxane complexes.
The National Cancer Institute's benchmark 60 cell line panel is used to compare the efficacy of the copper- Taxol and copper-taxol-hydroxychloroquin complexes to that of iron- taxol and pure taxol. Expand
Total synthesis of bryostatin 1.
The first total synthesis of Bryostatin 1 is described, which is a highly convergent one in which the preformed, heavily functionalized pyran rings A and C are united by "pyran annulation", the TMSOTf-promoted reaction between a hydroxyallylsilane appended to the A-ring fragment and an aldehyde contained in the C-ring fragments. Expand
Bryostatin-1: A Novel PKC Inhibitor in Clinical Development
Bryostatin-1 is a macrocyclic lactone derived from a marine invertebrate that binds to the regulatory domain of protein kinase C that inhibits proliferation, induces differentiation, and promotes apoptosis in numerous hematological and solid tumor cell lines. Expand
“Picolog,” a Synthetically-Available Bryostatin Analog, Inhibits Growth of MYC-Induced Lymphoma In Vivo
The first in vivo validation that the bryostatin analog, picolog, is a potential therapeutic agent for the treatment of cancer and other diseases is provided. Expand
Bryostatin-1: pharmacology and therapeutic potential as a CNS drug.
In preclinical studies bryostatin-1 has been shown at appropriate doses to have cognitive restorative and antidepressant effects, and the therapeutic potential of bryosteroids as a CNS drug should be further explored. Expand
Identifying bryostatins and potential precursors from the bryozoan Bugula neritina
Extracts of 14 marine species of the Gulf of Mexico, from the sand trout to chicken liver sponge, all recently collected, are examined, to raise the question if the bryozoans are the original source of bryostatin. Expand
Translating Nature's Library: The Bryostatins and Function-Oriented Synthesis.
We review in part our computational, design, synthesis, and biological studies on a remarkable class of compounds and their designed analogs that have led to preclinical candidates for the treatmentExpand
The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.
Like bryostatin, acetal 7c exhibited significant levels of in vitro growth inhibitory activity against several human cancer cell lines, providing an important step toward the development of simplified, synthetically accessible analogs of the b Bryostatins. Expand
Total Synthesis of Bryostatin 2
The total synthesis of the marine macrolide bryostatin 2 is described. The synthesis plan relies on aldol and directed reduction steps in order to construct the anti-1,3-diol array present in each ofExpand