Isolation, Structure, Synthesis and Cytotoxicity of an Unprecedented Flupirtine Dimer

  title={Isolation, Structure, Synthesis and Cytotoxicity of an Unprecedented Flupirtine Dimer},
  author={Ren{\'e} Csuk and Sven Sommerwerk and Jan Wiese and Christoph Wagner and Bianka Siewert and Ralph Kluge and Dieter Str{\"o}hl},
  journal={Zeitschrift f{\"u}r Naturforschung B},
  pages={1297 - 1304}
A previously unknown dimer of the well-established analgesic flupirtine has been found, and its structure was revealed by ESI-MS, NMR spectroscopy and an independent synthesis. Thus, starting from 2-amino-6-chloro-3-nitro-pyridine the target compound was obtained in a four-step synthesis. Key-step of this synthesis is a nickel-mediated aryl-aryl coupling. The dimer 4 did not show any cytotoxicity, and its IC50 values were > 30 μm for all six human cancer cell lines and mouse fibroblasts used in… 
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