Isolated tumor cells in regional lymph nodes as relapse predictors in stage I and II colorectal cancer.

Abstract

PURPOSE Lymph node (LN) involvement is the most important prognostic factor in colorectal cancer (CRC), and pN-positive status identifies patients who require adjuvant chemotherapy. Approximately 15% to 20% of patients without nodal metastases (pN0) develop recurrent disease. In this study, we tested the prognostic significance of isolated tumor cells (ITCs… (More)
DOI: 10.1200/JCO.2011.35.9539

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