Isolated testicular relapse in acute lymphoblastic leukemia - effective treatment with the modified CCG-112 protocol.


BACKGROUND The testes have been considered a sanctuary site for leukemic cells and testicular relapses used to account for a major proportion of the poor outcome of boys with acute lymphoblastic leukemia. With use of aggressive chemotherapy which includes intermediate or high dose methotrexate, the incidence of testicular relapses has declined. However once… (More)


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