Isolated systolic hypertension in the elderly
@article{Chobanian2007IsolatedSH, title={Isolated systolic hypertension in the elderly}, author={Aram V. Chobanian}, journal={The New England Journal of Medicine}, year={2007}, volume={357}, pages={789-796} }
Key MethodA 68-year-old accountant visits his physician. A year earlier he was told that his blood pressure was somewhat elevated and was advised to reduce salt intake and increase activity. Otherwise, he has been in good health and has no history or signs of cardiovascular or renal disease. On physical examination, his blood pressure is 178/72 mm Hg, and his body-mass index is 28.4. How should he be further evaluated and treated?
106 Citations
HYPERTENSION IN ELDERLY:OUR CURRENT TRENDS
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A literature review of trials published in English in the last 10 years designed to study the effectiveness and safety of various BP targets in patients who are 70 years or older found that the benets in the positive studies were demonstrated even with a minimal BPcontrol and continued to be reported for a SBP<120 mmHg.
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A literature review of trials published in English in the last 10 years designed to study the efficacy and safety of various BP targets in patients who are 70 years or older found that the benefits in the positive studies were demonstrated even with a minimal BP control and continued to be reported for a SBP <120 mmHg.
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In the elderly and very elderly (˃80 years), a wealth of data from large clinical trials are available, showing the necessity of treatment mostly with drug combinations—fix combinations are preferred for increasing the adherence/persistence to therapy.
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- 2018
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An age-differential association between SUA level and incident hypertension among Koreans is observed, which can be a trigger for hypertension through early vascular changes in the middle-aged population.
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Despite being well controlled and normotensive control subjects at rest, ISH patients had high SBP responses to both dynamic and static exercises, which may constitute a risk for cardiovascular incidents.
Treatment strategies for isolated systolic hypertension in elderly patients
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- 2020
The authors systematically review published studies to appraise the scientific and clinical evidence supporting the role of blood pressure control in elderly patients with isolated systolic hypertension, and to assess the influence of different drug treatment regimens on outcomes.
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AT1 receptor antagonists represent an appropriate option for many elderly patients with hypertension, type 2 diabetes, heart failure, and/or left ventricular dysfunction, including potential for improved adherence, excellent tolerability profile with minimal first-dose hypotension, and a low incidence of adverse effects.
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