Isolated pulmonary Langerhans cell histiocytosis with recurrent bilateral pneumothoraces treated with chemotherapy and chemical pleurodesis

  title={Isolated pulmonary Langerhans cell histiocytosis with recurrent bilateral pneumothoraces treated with chemotherapy and chemical pleurodesis},
  author={Lubbna Valliani and V. Kanwar and A Schwartz},
  journal={Pediatric Blood \& Cancer},
increased and prolonged calcium folinate rescue. Nevertheless, there is a certain incidence of subacute neurotoxicity independent of MTX pharmacokinetics. We observed delayed neurotoxicity in an osteosarcoma patient following a 4 hour 12 g/mMTX infusion and rescued by calcium folinate from hours 28 to 90. Even in protocols including administration of folinate after any single intrathecal MTX dosage subacute neurotoxicity is observed occasionally as recently reported [5]. The fact that in all of… Expand
3 Citations
Paediatric pulmonary Langerhans cell histiocytosis
An overview of paediatric pulmonary Langerhans cell histiocytosis is given, with a focus on the diagnosis, monitoring and management of complications such as pneumothoraces and respiratory failure, which can be challenging for the paediatric respiratory specialist. Expand
Management of severe pulmonary Langerhans cell histiocytosis in children
Patients with extraordinary amounts of pulmonary cystic disease and multiple pneumothoraces due to LCH can have remarkable, curative outcomes with early recognition, optimal LCH‐directed therapy, and supportive care. Expand
Pleurodesis in pulmonary langerhans cell histiocytosis in children: A life-saving measure
A young girl with isolated pulmonary LCH who presented with respiratory failure, successfully treated with chemotherapy, and pleurodesis is reported here to highlight the use of pleuradesis in this setting. Expand


Isolated pulmonary Langerhans cell histiocytosis presenting with recurrent pneumothorax
Conservative surgical treatment and moderate chemotherapy produced good results in these two rare cases of acutely developed severe respiratory distress with tachypnea, cyanosis and thoracic pain. Expand
Natural Course of Isolated Pulmonary Langerhans’ Cell Histiocytosis in a Toddler
A case of LCH restricted to the lungs in a toddler whose parents were heavy smokers, which appears that the evolution of fibrosis is rather a result from the accumulating alveolar macrophages than from the persistence of the Langerhans’ cells. Expand
Pneumothorax in pulmonary Langerhans cell histiocytosis.
Data from this retrospective study support the early use of surgical therapy with pleurodesis in managing patients with PLCH and spontaneous pneumothorax. Expand
Severe isolated pulmonary Langerhans cell histiocytosis in a 6-year-old girl
A 6-year-old girl with progressive pulmonary insufficiency, onset of clubbing at 4 years of age and honeycombing lung infiltrations on X-ray films, and radiological suspicion of primary pulmonary LCH, which should be considered in the aetiology of cystic lung diseases. Expand
Recurrent intrathecal methotrexate induced neurotoxicity in an adolescent with acute lymphoblastic leukemia: Serial clinical and radiologic findings
The case of an adolescent male with T‐cell ALL who developed recurrent episodes of subacute neurotoxicity characterized by slurred speech, emotional lability, and hemiparesis after intrathecal MTX administration is described. Expand
“Primary” Pulmonary Langerhans Cell Histiocytosis in a Two-Year-Old Child: Case Report and Literature Review
Pulmonary histiocytosis, though rare, should be considered in any child with chronic respiratory disease such as bronchial asthma, especially when the response to anti-asthma treatment is poor and/or there are cystic changes on the chest x-ray. Expand
Biochemical and Clinical Aspects of Methotrexate Neurotoxicity
A better understanding of the pathogenesis of MTX neurotoxicity would offer the possibility of developing new therapeutic strategies for its treatment or prevention. Expand
Pulmonary Langerhans cell histiocytosis: A variable disease in childhood
A retrospective study describes the clinical manifestation, course, and outcome of PLCH in children consecutively diagnosed at two Canadian institutions. Expand
Recurrent pneumomediastinum and pneumothorax in Langerhans cell histiocytosis.
Three children who developed recurrent intrathoracic air leaks are reported and the use of extracorporeal membrane oxygenation as an alternative to intermittent positive pressure ventilation in children with respiratory failure from Langerhans cell histiocytosis is discussed. Expand
High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia
The results suggest that high doses of LV increase the risk for relapse despite the fact that they were correlated with high MTX levels and longer MTX elimination time. Expand