Isolated presynaptic inotropic beta-adrenergic supersensitivity of the transplanted denervated human heart in vivo.

@article{Scheidt1992IsolatedPI,
  title={Isolated presynaptic inotropic beta-adrenergic supersensitivity of the transplanted denervated human heart in vivo.},
  author={Wolfgang von Scheidt and Michael Boehm and Barbara Schneider and B. W. Carney G. N. Cecil C. R. Evans H. J. Karwowski Reichart and Erland Erdmann and G Autenrieth},
  journal={Circulation},
  year={1992},
  volume={85 3},
  pages={1056-63}
}
BACKGROUND The regulation of contractility of the transplanted heart depends on circulating catecholamines resulting from cardiac denervation. Supersensitivity to circulating catecholamines may result from loss of presynaptic neuronal uptake or upregulation of postsynaptic beta-adrenergic receptors. METHODS AND RESULTS Dose-response curves using the beta-adrenergic receptor agonists isoprenaline (no neuronal uptake) and epinephrine (neuronal uptake) were performed in vivo. The inotropic… CONTINUE READING

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