Isolated precocious pubarche: an approach.

  title={Isolated precocious pubarche: an approach.},
  author={Rina Balducci and Brunetto Boscherini and A Mangiantini and Marina Morellini and Vincenzo Toscano},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={79 2},
Precocious pubarche (PP) is most often a benign condition secondary to the early appearance of adrenarche. However, PP may be a manifestation of nonclassical adrenal hyperplasia. The incidence of nonclassical adrenal hyperplasia in patients with PP ranges from about 0-40% of cases. Controversy exists as to whether all children with PP should undergo an ACTH stimulation test. The aim of this study was 1) to determine the frequency of mild adrenal enzyme defects in a very large and ethnically… CONTINUE READING


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