Isolated left ventricular noncompaction is rarely caused by mutations in G4.5, alpha-dystrobrevin and FK Binding Protein-12.

@article{Kenton2004IsolatedLV,
  title={Isolated left ventricular noncompaction is rarely caused by mutations in G4.5, alpha-dystrobrevin and FK Binding Protein-12.},
  author={Alexander B Kenton and Ximena Sanchez and Karen J. Coveler and Kimberly A Makar and Shinawe Jimenez and Fukiko Ichida and Ross R T Murphy and Perry M Elliott and W Mckenna and Neil E. Bowles and Jeffrey Allen Towbin and Karla R. Bowles},
  journal={Molecular genetics and metabolism},
  year={2004},
  volume={82 2},
  pages={162-6}
}
Isolated left ventricular noncompaction (LVNC) is a form of cardiomyopathy that most commonly presents in infancy with a hypertrophic and dilated left ventricle characterized by deep trabeculations and intertrabecular recesses. Our goal was to determine the frequency of mutations in G4.5, alpha-dystrobrevin, and FK Binding protein-12 in isolated LVNC patients. No mutations were identified in 47 of the 48 patients studied, while a splice site acceptor site mutation of intron 10 of G4.5 was… CONTINUE READING

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