Isolated human germinal center centroblasts have an intact mismatch repair system.

@article{Park1998IsolatedHG,
  title={Isolated human germinal center centroblasts have an intact mismatch repair system.},
  author={K Park and J M Kim and Hy Sook Kim and Hyun Sung Shin},
  journal={Journal of immunology},
  year={1998},
  volume={161 11},
  pages={6128-32}
}
Ig somatic hypermutation contributes to the generation of high-affinity Abs that are essential for efficient humoral defense. The presence of multiple point mutations in rearranged Ig V genes and their immediate flanking sequences suggests that the DNA repair system may not be working properly in correcting point mutations introduced to the restricted region of Ig genes. We examined the DNA repair functions of germinal center (GC) centroblasts, which are the cells in which ongoing Ig… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…