Isolated biomolecules of pharmacological interest in hemostasis from Cerastes cerastes venom

@inproceedings{Chrifi2012IsolatedBO,
  title={Isolated biomolecules of pharmacological interest in hemostasis from Cerastes cerastes venom},
  author={Fatah Ch{\'e}rifi and Fatima Laraba-Djebari},
  booktitle={Journal of Venomous Animals and Toxins including Tropical Diseases},
  year={2012}
}
Biomolecules from Cerastes cerastes venom have been purified and characterized. Two phospholipases isolated from Cerastes cerastes venom share 51% of homology. CC2-PLA2 exhibits antiplatelet activity that blocks coagulation. CCSV-MPase, a non-hemorrhagic Zn2+-metalloproteinase, significantly reduced the plasmatic fibrinogen level and hydrolyzes only its Bβ chain. Serine proteinases such as RP34, afaâcytin and CC3-SPase hydrolyze the fibrinogen and are respectively α, αβ and αβ fibrinogenases… CONTINUE READING
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