Isolated amyloid-β(1-42) protofibrils, but not isolated fibrils, are robust stimulators of microglia.

@article{Paranjape2012IsolatedAP,
  title={Isolated amyloid-β(1-42) protofibrils, but not isolated fibrils, are robust stimulators of microglia.},
  author={Geeta S. Paranjape and Lisa K. Gouwens and David C Osborn and Michael R Nichols},
  journal={ACS chemical neuroscience},
  year={2012},
  volume={3 4},
  pages={302-11}
}
Senile plaques composed of amyloid-β protein (Aβ) are an unshakable feature of the Alzheimer's disease (AD) brain. Although there is significant debate on the role of the plaques in AD progression, there is little disagreement on their role in stimulating a robust inflammatory response within the context of the disease. Significant inflammatory markers such… CONTINUE READING