Isolated Limb Perfusion in the Management of Patients With Recurrent Limb Melanoma: An Important but Limited Role


Isolated limb perfusion (ILP) was introduced into clinical practice in the mid-1950s, based on the same principles that had been applied to develop extracorporeal cardiopulmonary bypass a few years earlier. The concept was simple. By temporarily isolating the vasculature of a limb, high cytotoxic drug concentrations could be achieved without producing… (More)
DOI: 10.1007/s10434-001-0564-9