Isolated Hypoxic Hepatic Perfusion with Retrograde Outflow in Patients with Irresectable Liver Metastases; A New Simplified Technique in Isolated Hepatic Perfusion

@article{Verhoef2007IsolatedHH,
  title={Isolated Hypoxic Hepatic Perfusion with Retrograde Outflow in Patients with Irresectable Liver Metastases; A New Simplified Technique in Isolated Hepatic Perfusion},
  author={Cornelis Verhoef and Johannes H W de Wilt and Fl{\'a}via Brunstein and Andreas W. K. S. Marinelli and Boudewijn van Etten and Maarten Vermaas and Gunther Guetens and Gert de Boeck and Ernst A. de Bruijn and Alexander Eggermont},
  journal={Annals of Surgical Oncology},
  year={2007},
  volume={15},
  pages={1367 - 1374}
}
Isolated hepatic perfusion with high-dose chemotherapy is a treatment option for patients with irresectable metastases confined to the liver. Prolonged local control and impact on survival have been claimed. Major drawbacks are magnitude and costs of the procedure. We developed an isolated hypoxic hepatic perfusion (IHHP) with retrograde outflow without the need for a heart-lung machine. Twenty-four consecutive patients with irresectable metastases of various origins were treated. IHHP inflow… CONTINUE READING

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