Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation.

@article{Huper2007IsogenicNB,
  title={Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation.},
  author={Gudrun Huper and Jeffrey R. Marks},
  journal={Cancer research},
  year={2007},
  volume={67 7},
  pages={2990-3001}
}
Epithelial cells within the normal breast duct seem to be the primary target for neoplastic transformation events that eventually produce breast cancer. Normal epithelial cells are easily isolated and propagated using standard techniques. However, these techniques almost invariably result in populations of cells that are largely basal in character. Because only approximately 20% of human breast cancers exhibit a basal phenotype, our understanding of the disease may be skewed by using these… CONTINUE READING

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Are all high-grade breast cancers with no steroid receptor hormone expression alike? The special case of the medullary phenotype.

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