Isogenic mutants of the cag pathogenicity island of Helicobacter pylori in the mouse model of infection: effects on colonization efficiency.

@article{Marchetti2002IsogenicMO,
  title={Isogenic mutants of the cag pathogenicity island of Helicobacter pylori in the mouse model of infection: effects on colonization efficiency.},
  author={Marta Marchetti and Rino Rappuoli},
  journal={Microbiology},
  year={2002},
  volume={148 Pt 5},
  pages={1447-56}
}
Strains of Helicobacter pylori that contain the cag pathogenicity island (cag PAI) are associated with increased virulence and severe clinical outcomes. To evaluate the role of the cag island in infection, isogenic null mutations were generated in two clinical isolates (SS1 and Iris1) with distinct genetic backgrounds. When tested for their ability to… CONTINUE READING