Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease

@article{Hotta2016IsogenicEN,
  title={Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease},
  author={Ryo Hotta and L S Cheng and Hannah K Graham and Weihua Pan and N{\'a}ndor Nagy and Jaime Belkind-Gerson and Allan M. Goldstein},
  journal={Neurogastroenterology \& Motility},
  year={2016},
  volume={28}
}
Transplanting autologous patient‐derived enteric neuronal stem/progenitor cells (ENSCs) is an innovative approach to replacing missing enteric neurons in patients with Hirschsprung disease (HSCR). Using autologous cells eliminates immunologic and ethical concerns raised by other cell sources. However, whether postnatal aganglionic bowel is permissive for transplanted ENSCs and whether ENSCs from HSCR patients can be successfully isolated, cultured, and transplanted in vivo remains unknown. 
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The significance of recent advances in cell therapy, which transplanted human enteric neural progenitors into the mouse colon and shown engraftment, are summarized and priorities for future research are discussed that might lead to the use of regenerative medicine to treat enteric neuropathies in the clinic.
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  • 2017
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Update on the Role of Stem Cells in the Treatment of Hirschsprung Disease
  • Kathy Nga-Chu Lui, P. Tam, E. S. Ngan
  • Medicine
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
  • 2018
TLDR
The potential applications of somatic stem cells and iPSCs for the cell‐based therapy of HSCR are discussed and the recent advances in stem cell research are highlighted for the establishment of human H SCR models for the development of novel therapies.
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