Isofurans: novel products of lipid peroxidation that define the occurrence of oxidant injury in settings of elevated oxygen tension.

@article{Fessel2005IsofuransNP,
  title={Isofurans: novel products of lipid peroxidation that define the occurrence of oxidant injury in settings of elevated oxygen tension.},
  author={Joshua Patrick Fessel and L. Jackson Roberts},
  journal={Antioxidants & redox signaling},
  year={2005},
  volume={7 1-2},
  pages={202-9}
}
We recently reported the discovery of isofurans, novel products of free radical-induced peroxidation of arachidonic acid that exhibit favored formation with increasing oxygen concentrations. In this review, the biochemistry of isofuran formation is compared with that of isoprostanes, with an emphasis on the mechanistic basis for the favored formation of isofurans at elevated oxygen tensions. In addition, the formation of isofurans in various disease states in vivo is also discussed. Parkinson's… CONTINUE READING