Isoform specificity of the Na/K-ATPase association and regulation by phospholemman.

  title={Isoform specificity of the Na/K-ATPase association and regulation by phospholemman.},
  author={Julie Bossuyt and Sanda Despa and Fei Han and Zhanjia Hou and Seth L Robia and Jerry B. Lingrel and Donald M. Bers},
  journal={The Journal of biological chemistry},
  volume={284 39},
Phospholemman (PLM) phosphorylation mediates enhanced Na/K-ATPase (NKA) function during adrenergic stimulation of the heart. Multiple NKA isoforms exist, and their function/regulation may differ. We combined fluorescence resonance energy transfer (FRET) and functional measurements to investigate isoform specificity of the NKA-PLM interaction. FRET was measured as the increase in the donor fluorescence (CFP-NKA-alpha1 or CFP-NKA-alpha2) during progressive acceptor (PLM-YFP) photobleach in HEK… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 30 extracted citations


Publications referenced by this paper.

hp://w w w D

  • J. Wang, X. O. Zhang, +6 authors J. Y. Cheung
  • J Biol Chem
  • 2006
1 Excerpt

Similar Papers

Loading similar papers…