Isoform-specific silencing of the Livin gene by RNA interference defines Livin β as key mediator of apoptosis inhibition in HeLa cells
@article{CrnkoviMertens2005IsoformspecificSO, title={Isoform-specific silencing of the Livin gene by RNA interference defines Livin β as key mediator of apoptosis inhibition in HeLa cells}, author={I. Crnkovi{\'c}-Mertens and J. Semzow and F. Hoppe-Seyler and K. Butz}, journal={Journal of Molecular Medicine}, year={2005}, volume={84}, pages={232-240} }
Livin (alternatively called ML-IAP or KIAP) is a cancer-associated member of the antiapoptotic inhibitor of apoptosis protein family. Two splicing variants of Livin, designated Livin α and Livin β, have been identified. The significance of these isoforms for Livin-mediated apoptosis inhibition is largely unclear. Using an isoform-specific RNA interference (RNAi) strategy, we silenced endogenous Livin expression in HeLa cells. We found that the targeted inhibition of Livin β, but not of Livin… CONTINUE READING
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References
SHOWING 1-10 OF 38 REFERENCES
Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene
- Biology, Medicine
- Oncogene
- 2003
- 101
- PDF
Livin, a Novel Inhibitor of Apoptosis Protein Family Member*
- Medicine, Biology
- The Journal of Biological Chemistry
- 2001
- 439
- PDF
Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma.
- Biology, Medicine
- Cancer research
- 2003
- 111
- PDF
siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells
- Medicine, Biology
- Oncogene
- 2003
- 330
- PDF
Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern
- Biology, Medicine
- FEBS letters
- 2001
- 168
- Highly Influential
IAP Suppression of Apoptosis Involves Distinct Mechanisms: the TAK1/JNK1 Signaling Cascade and Caspase Inhibition
- Biology, Medicine
- Molecular and Cellular Biology
- 2002
- 224
- PDF
SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)*
- Biology, Medicine
- The Journal of Biological Chemistry
- 2002
- 167
- PDF
Detection of anti-livin antibody in gastrointestinal cancer patients.
- Biology, Medicine
- Clinical chemistry
- 2003
- 80
- PDF
Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties.
- Biology, Medicine
- Cancer research
- 1999
- 389