Isoform specific requirement for GSK3α in sperm for male fertility.

Abstract

Glycogen synthase kinase 3 (GSK3) is a highly conserved protein kinase regulating key cellular functions. Its two isoforms, GSK3α and GSK3β, are encoded by distinct genes. In most tissues the two isoforms are functionally interchangeable, except in the developing embryo where GSK3β is essential. One functional allele of either of the two isoforms is… (More)
DOI: 10.1093/biolre/ioy020

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