Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

@article{Bae2003IsoformspecificRO,
  title={Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.},
  author={Sun Sik Bae and Han Cho and James Mu and Morris J Birnbaum},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 49},
  pages={49530-6}
}
Recent data have implicated the serine/threonine protein kinase Akt/protein kinase B (PKB) in a diverse array of physiological pathways, raising the question of how biological specificity is maintained. Partial clarification derived from the observation that mice deficient in either of the two isoforms, Akt1/PKBalpha or Akt2/PKBbeta, demonstrate distinct abnormalities, i.e. reduced organismal size or insulin resistance, respectively. However, the question still persists as to whether these… CONTINUE READING
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