Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors.

@article{Edgar2010IsoformspecificP3,
  title={Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors.},
  author={Kyle A. Edgar and Jeffrey J. Wallin and Megan E. Berry and L. Breakwell Lee and Wei Wei Prior and Deepak Sampath and Lori S. Friedman and Marcia Belvin},
  journal={Cancer research},
  year={2010},
  volume={70 3},
  pages={
          1164-72
        }
}
Therapeutic inhibitors are being developed against the phosphoinositide 3-kinase (PI3K) pathway, the deregulation of which drives tumor growth and survival in many cancers. There are eight PI3Ks in mammals divided into three classes. Class IA PI3Ks (p110alpha, p110beta, and p110delta) are critical for cell growth and survival, with the p110alpha isoform implicated as the most important in carcinomas. In this study, we examined the effects of small-molecule inhibitors of class IA PI3Ks to… CONTINUE READING

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