Isoform-specific monoclonal antibodies against 3β-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism.

@article{Doi2014IsoformspecificMA,
  title={Isoform-specific monoclonal antibodies against 3β-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism.},
  author={Masao Doi and Fumitoshi Satoh and Takashi Maekawa and Yasuhiro Nakamura and J M Fustin and Motomi Tainaka and Yunhong Hotta and Yukari Takahashi and Ryo Morimoto and K Takase and Sadayoshi Ito and Hironobu Sasano and Hitoshi Okamura},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2014},
  volume={99 2},
  pages={E257-62}
}
CONTEXT Therapeutic management of primary aldosteronism requires accurate differentiation between aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA). However, little is known about the molecular features that delineate the difference between APA and IHA. Two different isoforms of 3β-hydroxysteroid dehydrogenase (HSD3B1 and HSD3B2) are thought to be expressed in the human adrenal gland, but the lack of isoform-specific antibody has so far hampered mapping of these… CONTINUE READING

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