Isoform-specific modulation of coronary artery PKC by glucocorticoids.

  title={Isoform-specific modulation of coronary artery PKC by glucocorticoids.},
  author={Kamala K. Maddali and Donna H Korzick and James R. Turk and Douglas K. Bowles},
  journal={Vascular pharmacology},
  volume={42 4},
Glucocorticoids (GC) exert diverse cellular effects in response to both acute and chronic stress, the functional consequences of which have been implicated in the development of cardiovascular pathology such as hypertension and atherosclerosis. However, the mechanisms by which GCs activate divergent signaling pathways are poorly understood. The present study examined the direct effects of natural (cortisol) and synthetic (dexamethasone) GCs on protein kinase C (PKC) isoform expression in… CONTINUE READING


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