Isoform-specific knockout of FE65 leads to impaired learning and memory.

@article{Wang2004IsoformspecificKO,
  title={Isoform-specific knockout of FE65 leads to impaired learning and memory.},
  author={Baiping Wang and Qubai Hu and Mark G. Hearn and Kimiko Shimizu and Carol B Ware and Dennis H Liggitt and Lee-way Jin and Bethany H. Cool and Daniel R Storm and George M. Martin},
  journal={Journal of neuroscience research},
  year={2004},
  volume={75 1},
  pages={12-24}
}
FE65 is a multimodular adapter protein that is expressed predominantly in brain. Its C-terminal phosphotyrosine interaction domain (PID) binds to the intracellular tail of the beta-amyloid precursor protein (betaPP), a protein of central importance to the pathogenesis of dementias of the Alzheimer type. To study the physiological functions of FE65, we generated a line of FE65 knockout mice via gene targeting. By Western analysis with a panel of FE65-specific antibodies, we demonstrate that the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

A role for FE65 in controlling GnRH-1 neurogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2011
View 13 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…