Isoform-specific knockout of FE65 leads to impaired learning and memory.

  title={Isoform-specific knockout of FE65 leads to impaired learning and memory.},
  author={Baiping Wang and Qubai Hu and Mark G. Hearn and Kimiko Shimizu and Carol B Ware and Dennis H Liggitt and Lee-way Jin and Bethany H. Cool and Daniel R Storm and George M. Martin},
  journal={Journal of neuroscience research},
  volume={75 1},
FE65 is a multimodular adapter protein that is expressed predominantly in brain. Its C-terminal phosphotyrosine interaction domain (PID) binds to the intracellular tail of the beta-amyloid precursor protein (betaPP), a protein of central importance to the pathogenesis of dementias of the Alzheimer type. To study the physiological functions of FE65, we generated a line of FE65 knockout mice via gene targeting. By Western analysis with a panel of FE65-specific antibodies, we demonstrate that the… CONTINUE READING


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