Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1 (HP1).

Abstract

Three mammalian isoforms of heterochromatin protein 1 (HP1), α, β, and γ, play diverse roles in gene regulation. Despite their structural similarity, the diverse functions of these isoforms imply that they are additionally regulated by post-translational modifications. Here, we have identified intermolecular disulfide bond formation of HP1 cysteines in an… (More)
DOI: 10.1074/jbc.M110.155788

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