Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

@article{Strittmatter1994IsoformspecificIO,
  title={Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.},
  author={Warren J. Strittmatter and Ann M Saunders and Michel Goedert and Karl H. Weisgraber and Lenny Dong and Ross Jakes and David Y. C. Huang and Margaret A. Pericak-Vance and Donald E. Schmechel and A. D. Roses},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 23},
  pages={11183-6}
}
The apolipoprotein E (apoE) type 4 allele (APOE4) is a susceptibility gene for late-onset familial and sporadic Alzheimer disease. ApoE is found in some neurofibrillary tangle-bearing neurons, one of the major pathologic hallmarks of the disease. Neurofibrillary tangles contain paired helical filaments formed from hyperphosphorylated microtubule-associated protein tau. In vitro, tau binds avidly to apoE3, but not to apoE4, forming a bimolecular complex. Tau phosphorylated with a brain extract… CONTINUE READING
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