Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo.

@article{Ali2008IsoformspecificFO,
  title={Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo.},
  author={Khaled Ali and Montserrat Camps and Wayne P. Pearce and Hong Ji and Thomas Rueckle and Nicolas K{\"u}hn and Christian Pasquali and Christian Chabert and Christian Rommel and Bart Vanhaesebroeck},
  journal={Journal of immunology},
  year={2008},
  volume={180 4},
  pages={2538-44}
}
The leukocyte-enriched p110gamma and p110delta isoforms of PI3K have been shown to control in vitro degranulation of mast cells induced by cross-linking of the high affinity receptor of IgE (FcepsilonRI). However, the relative contribution of these PI3K isoforms in IgE-dependent allergic responses in vivo is controversial. A side-by-side comparative analysis of the role of p110gamma and p110delta in mast cell function, using genetic approaches and newly developed isoform-selective pharmacologic… CONTINUE READING

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