Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice.

@article{Yoshida2001IsoformspecificEO,
  title={Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice.},
  author={Haruna Yoshida and Alyssa H Hasty and Amy S. Major and Hiroyuki Ishiguro and Yan Ru Su and Linda A. Gleaves and Vladimir R. Babaev and Macrae F Linton and Sergio Fazio},
  journal={Circulation},
  year={2001},
  volume={104 23},
  pages={2820-5}
}
BACKGROUND We recently used a bone marrow-based gene therapy approach to show that small amounts of retrovirus-derived human apolipoprotein E3 (apoE3) produced by macrophages are protective against early atherosclerosis in apoE-deficient mice. METHODS AND RESULTS In the present study, we evaluated whether the effect produced by macrophage-derived apoE3 is related to its ability to bind cellular membranes. To this end, we used apoE2 and apoEcys142, dysfunctional human variants with reduced… CONTINUE READING