Isoform-specific early trafficking of AMPA receptor flip and flop variants.

  title={Isoform-specific early trafficking of AMPA receptor flip and flop variants.},
  author={Sarah K. Coleman and Tommi M{\"o}ykkynen and Chunlin Cai and Lotta von Ossowski and Esa Kuismanen and Esa R Korpi and Kari Kein{\"a}nen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={26 43},
Flip and flop splice variants of AMPA receptor subunits are expressed in distinct but partly overlapping patterns and impart different desensitization kinetics to cognate receptor channels. In the absence of specific antibodies, isoform-specific differences in trafficking or localization of native flip and flop subunits remain uncharacterized. We report that in several transfected cell lines, transport of homomeric glutamate receptor (GluR)-D(flop) receptors is largely blocked at the… CONTINUE READING