Isoform-specific distribution of the plasma membrane Ca2+ ATPase in the rat brain.

  title={Isoform-specific distribution of the plasma membrane Ca2+ ATPase in the rat brain.},
  author={Alain C. Burette and Julia M Rockwood and Emanuel E. Strehler and Richard J. Weinberg},
  journal={The Journal of comparative neurology},
  volume={467 4},
Regulation of cytoplasmic calcium is crucial both for proper neuronal function and cell survival. The concentration of Ca2+ in cytoplasm of a neuron at rest is 10,000 times lower than in the extracellular space, pointing to the importance of the transporters that extrude intracellular Ca2+. The family of plasma membrane calcium-dependent ATPases (PMCAs) represent a major component of the Ca2+ regulatory system. However, little information is available on the regional and cellular distribution… CONTINUE READING

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