Isoform-specific differences between Rap1A and Rap1B GTPases in the formation of endothelial cell junctions.

@article{Wittchen2011IsoformspecificDB,
  title={Isoform-specific differences between Rap1A and Rap1B GTPases in the formation of endothelial cell junctions.},
  author={Erika S. Wittchen and Amir Aghajanian and Keith Burridge},
  journal={Small GTPases},
  year={2011},
  volume={2 2},
  pages={65-76}
}
Rap1 is a Ras-like GTPase that has been studied with respect to its role in cadherin-based cell adhesion. Rap1 exists as two separate isoforms, Rap1A and Rap1B, which are 95% identical and yet the phenotype of the isoform-specific knockout mice is different. We and others have previously identified a role for Rap1 in regulating endothelial adhesion, junctional integrity and barrier function; however, these early studies did not distinguish a relative role for each isoform. To dissect the… CONTINUE READING