Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients

@article{Cozzone2007IsoformspecificDO,
  title={Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients},
  author={Delphine Cozzone and Sara Fr{\"o}jd{\"o} and Emmanuel Disse and Cyrille Debard and Martine Laville and Luciano Pirola and Hubert Vidal},
  journal={Diabetologia},
  year={2007},
  volume={51},
  pages={512-521}
}
The serine/threonine kinase Akt/protein kinase B (PKB) is required for the metabolic actions of insulin. Controversial data have been reported regarding Akt defective activation in the muscle of type 2 diabetic patients. Because three Akt isoforms exist, each having a distinct physiological role, we investigated the contribution of isoform-specific defects to insulin signalling in human muscle. The phosphorylation pattern and kinase activity of each Akt isoform were compared in primary myotubes… CONTINUE READING
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