Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds.

@article{Brand2013IsoformSO,
  title={Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds.},
  author={Cameron S. Brand and Harrison J. Hocker and Alemayehu A. Gorfe and Claudio N. Cavasotto and Carmen W. Dessauer},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2013},
  volume={347 2},
  pages={265-75}
}
Nine membrane-bound adenylyl cyclase (AC) isoforms catalyze the production of the second messenger cyclic AMP (cAMP) in response to various stimuli. Reduction of AC activity has well documented benefits, including benefits for heart disease and pain. These roles have inspired development of isoform-selective AC inhibitors, a lack of which currently limits… CONTINUE READING