Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes.

@article{Mller2015IsoformselectiveRO,
  title={Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes.},
  author={Margit S. M{\"u}ller and Sofie E Pedersen and Anne B Walls and Helle S\onderby Waagepetersen and Lasse K Bak},
  journal={Glia},
  year={2015},
  volume={63 1},
  pages={154-62}
}
Glycogen phosphorylase (GP) is activated to degrade glycogen in response to different stimuli, to support both the astrocyte's own metabolic demand and the metabolic needs of neurons. The regulatory mechanism allowing such a glycogenolytic response to distinct triggers remains incompletely understood. In the present study, we used siRNA-mediated differential knockdown of the two isoforms of GP expressed in astrocytes, muscle isoform (GPMM), and brain isoform (GPBB), to analyze isoform-specific… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…