Isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulates arterial contractility.

@article{Adebiyi2010IsoformselectivePC,
  title={Isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulates arterial contractility.},
  author={Adebowale Adebiyi and Guiling Zhao and Damodaran Narayanan and Candice M. Thomas-Gatewood and John P. Bannister and Jonathan H Jaggar},
  journal={Circulation research},
  year={2010},
  volume={106 10},
  pages={1603-12}
}
RATIONALE Inositol 1,4,5-trisphosphate (IP(3))-induced vasoconstriction can occur independently of intracellular Ca(2+) release and via IP(3) receptor (IP(3)R) and canonical transient receptor potential (TRPC) channel activation, but functional signaling mechanisms mediating this effect are unclear. OBJECTIVES Study mechanisms by which IP(3)Rs stimulate TRPC channels in myocytes of resistance-size cerebral arteries. METHODS AND RESULTS Immunofluorescence resonance energy transfer (immuno… CONTINUE READING

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