Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis

@inproceedings{Zhan2015IsoformSO,
  title={Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis},
  author={Cheng Zhan and Li Yan and Lin Wang and Jun Ma and Wei Jiang and Yongxing Zhang and Yu Shi and Qun Wang},
  booktitle={PloS one},
  year={2015}
}
Muscle type of pyruvate kinase (PKM) is one of the key mediators of the Warburg effect and tumor metabolism. Due to alternative splicing, there are at least 12 known isoforms of the PKM gene, of which PKM1 and PKM2 are two major isoforms with only a 23 amino acid sequenced difference but quite different characteristics and functions. It was previously… CONTINUE READING