Isoform-Specific Regulation of the Na(+)-K(+) Pump in Heart.

  title={Isoform-Specific Regulation of the Na(+)-K(+) Pump in Heart.},
  author={Richard T. Mathias and Ira S. Cohen and Junyuan Gao and Youxue Wang},
  journal={News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society},
Guinea pig ventricular myocytes coexpress two isoforms of the Na(+)-K(+) pump. These two isoforms respond differently to the physical environment and are coupled to autonomic input through different signal transduction cascades. The expression of different isoforms provides each cell type with a mechanism of programming specific responses to environmental… CONTINUE READING