Isoflurane protects renal function against ischemia and reperfusion through inhibition of protein kinases, JNK and ERK.

@article{Hashiguchi2005IsofluranePR,
  title={Isoflurane protects renal function against ischemia and reperfusion through inhibition of protein kinases, JNK and ERK.},
  author={Hideo Hashiguchi and Hiroaki Morooka and Hiroshi Miyoshi and Masanori Matsumoto and Takehiko Koji and Koji Sumikawa},
  journal={Anesthesia and analgesia},
  year={2005},
  volume={101 6},
  pages={1584-9}
}
Isoflurane has a pharmacological preconditioning effect against ischemia in the heart and brain, but whether this also occurs in the kidney is unclear. In this study, we investigated pharmacological preconditioning by isoflurane in the rat kidney. In the isoflurane preconditioning group (1.5% isoflurane for 20 min before renal ischemia) serum creatinine (1.2 +/- 0.7 and 1.1 +/- 0.2 mg/dL) and blood urea nitrogen (99 +/- 29 and 187 +/- 31 mg/dL) were significantly smaller at 24 and 48 h after… CONTINUE READING
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