Isoflurane preconditions myocardium against infarction via release of free radicals.

@article{Mllenheim2002IsofluranePM,
  title={Isoflurane preconditions myocardium against infarction via release of free radicals.},
  author={Jost M{\"u}llenheim and Dirk Ebel and Jan Fraessdorf and Benedikt Preckel and Volker Th{\"a}mer and Wolfgang Schlack},
  journal={Anesthesiology},
  year={2002},
  volume={96 4},
  pages={934-40}
}
BACKGROUND Isoflurane exerts cardioprotective effects that mimic the ischemic preconditioning phenomenon. Generation of free radicals is implicated in ischemic preconditioning. The authors investigated whether isoflurane-induced preconditioning may involve release of free radicals. METHODS Sixty-one alpha-chloralose-anesthetized rabbits were instrumented for measurement of left ventricular (LV) pressure (tip-manometer), cardiac output (ultrasonic flowprobe), and myocardial infarct size… CONTINUE READING

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