Isoflurane inhibits insulin secretion from isolated rat pancreatic islets of Langerhans.

@article{Desborough1993IsofluraneII,
  title={Isoflurane inhibits insulin secretion from isolated rat pancreatic islets of Langerhans.},
  author={J P Desborough and Peter Martin Jones and Shanta J Persaud and M. P. J. Landon and Simon James Howell},
  journal={British journal of anaesthesia},
  year={1993},
  volume={71 6},
  pages={873-6}
}
We have investigated the effects of isoflurane on insulin secretion in vitro from rat isolated islets of Langerhans and found a significant, dose-related and reversible inhibition of insulin secretion. Isoflurane 2% decreased insulin secretion stimulated by glucose 20 mmol litre-1 to basal, nonstimulated values. In other studies to identify the stage in the stimulus secretion pathway for insulin at which the anaesthetic may exert an inhibitory action, we have stimulated insulin release using… CONTINUE READING