Isoflurane induces second window of preconditioning through upregulation of inducible nitric oxide synthase in rat heart.

@article{WakenoTakahashi2005IsofluraneIS,
  title={Isoflurane induces second window of preconditioning through upregulation of inducible nitric oxide synthase in rat heart.},
  author={Mayu Wakeno-Takahashi and Hajime Otani and Shinichi Nakao and Hiroji Imamura and Koh Shingu},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 6},
  pages={H2585-91}
}
The second window of preconditioning (SWOP) induced by inhalation of volatile anesthetics has been documented in the rat heart and is triggered by nitric oxide synthase (NOS), but involvement of NOS in the mediator phase of isoflurane-induced SWOP has not been demonstrated. We tested the hypothesis that isoflurane-induced SWOP is mediated through upregulation of inducible NOS (iNOS). Rats inhaled 0.75 minimum alveolar concentration (MAC) isoflurane, 1.5 MAC isoflurane, or O2 for 2 h. After 24… CONTINUE READING

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